Susanne Klute

This study identifies the IFN-STAT1/STAT5B-SOCS1 axis as a mechanism by which respiratory viruses activate autophagy, showing that targeting this pathway can inhibit virus replication without compromising innate immunity.

The paper identifies Laudanosine as an inhibitor of TPC2-dependent viral entry, effective against Ebola and related viruses without cytotoxicity.

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

This study identifies ARF1 as a negative regulator of cGAS-STING signaling, showing it prevents type I IFN induction by regulating STING activation and recycling.