Dual-mode ClfA-targeting DARPin biologics protect against diverse methicillin-resistant Staphylococcus aureus strains
Karuppiah Chockalingam, Biswarup Banerjee, Yu Zeng, Shuyu Miao, Joshua D. Bryant, Dominique M. Missiakas, Zhilei Chen
The paper develops dual-mode DARPin biologics that block both interfaces of ClfA, preventing S. aureus infections and offering protection against resistant strains.
bioRxiv · Jan 9, 2026 · PreprintMicrobiology