Glutamine-dependent downregulation of FLT3-ITD is a mechanism of FLT3 inhibitor resistance in FLT3-ITD AML in hypoxia
Giovannino Silvestri, Aditi Chatterjee, Blair P. Rendina, Eli E. Bar, Maria R. Baer
The paper investigates how hypoxia and glutamine affect FLT3 inhibitor resistance in FLT3-ITD AML, finding that glutamine reduces FLT3-ITD expression.
bioRxiv · May 15, 2026 · PreprintCancer Biology