Hypoxia-inducible factors drive miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer independent of 14q deletion
Soma Seal, Rebecca A. Luchtel, Talia Akram, Bogdan Isaila, Kent T. Perry, Daniele Procissi, Sassan Hafizi, Niraj Konchady Shenoy
This study identifies hypoxia-inducible factors (HIFs) as drivers of miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer, independent of 14q deletion, revealing a feedback loop and potential therapeutic targets.
bioRxiv · Dec 1, 2024 · PreprintCancer Biology