Rebecca A. Luchtel

In vivo anti-tumor activity of high-dose parenteral ascorbic acid is mediated primarily via cofactor activity, not via oxidative stress.

This study shows that high-dose parenteral ascorbic acid's anti-tumor effect in vivo is mainly due to cofactor activity, not oxidative stress, using mouse tumor models.

Hypoxia-inducible factors drive miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer independent of 14q deletion

This study identifies hypoxia-inducible factors (HIFs) as drivers of miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer, independent of 14q deletion, revealing a feedback loop and potential therapeutic targets.