Soma Seal

This study shows that high-dose parenteral ascorbic acid's anti-tumor effect in vivo is mainly due to cofactor activity, not oxidative stress, using mouse tumor models.

This study identifies hypoxia-inducible factors (HIFs) as drivers of miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer, independent of 14q deletion, revealing a feedback loop and potential therapeutic targets.

This study identifies nPIST as a novel actin binding protein in Purkinje cells, showing it interacts with GluRδ2 and stabilizes actin filaments through multiple binding regions.