BioengineeringbioRxivPreprint
✦ In-depth digest
Dynamic, single-cell monitoring of CAR T cell identity and activation with Raman spectroscopy
Ariel Stiber, Boi Bryant Quach, Babatunde Ogunlade…·Jennifer A. Dionne
Gold-nanorod surface-enhanced Raman spectroscopy with LightGBM separates CAR T from untransduced T cells, tracks antigen-specific activation dynamics, and discriminates sorted CAR+ from CAR- patient T cells.