Elena Sotillo

This paper introduces ORCA, a platform that uses oncogenic RNA sensing to target and ablate cancer cells, demonstrating efficacy in colorectal cancer models.

This paper develops GELYTACs, lysosome-targeting chimeras that deplete IgG in vivo via AAV delivery, showing sustained antibody depletion in mice.

Gold-nanorod surface-enhanced Raman spectroscopy with LightGBM separates CAR T from untransduced T cells, tracks antigen-specific activation dynamics, and discriminates sorted CAR+ from CAR- patient T cells.

This study investigates how cell cycle dynamics influence T cell fate and exhaustion by analyzing single-cell data and manipulating cell cycle progression and signaling.

The paper shows ibrutinib increases CD19 expression in B-cell lymphoma models, improving the effectiveness of CD19-CAR T cells.

This study shows that overexpressing clusterin (CLU) in T cells reduces exhaustion markers and improves their function against Ewing sarcoma.

ProVADA adapts proteins to non-native contexts by steering a pretrained generator while preserving function, successfully converting renin and deimmunizing antibodies.

This paper shows how recombining signaling motifs creates a continuous spectrum of CAR T cell phenotypes, revealing trade-offs between memory, cytotoxicity, and safety.

This study identifies IKAROS as a factor associated with antigen escape in B-ALL, showing that low IKAROS levels lead to reduced B-cell antigen expression and resistance to CD19- and CD22-targeted therapies.

The paper describes the development of genetically encodable LYTACs (GELYTACs) for targeted protein degradation using engineered T-cells, showing efficacy in secreting and delivering the therapeutics.

This paper introduces a novel CAR T cell platform using proximal T cell signaling molecules to enable Boolean logic-gated control, improving efficacy and reducing off-tumor toxicity.

The paper examines dynamic chromatin changes in human CAR T cells during exhaustion, identifying regulatory networks and enhancer roles in exhaustion-associated genes.