Parallel Arg/N-degron recognition systems regulate coenzyme A biosynthesis
Xiaolu Wang, Boju Wang, Liang Zhang, Shuxin Yan, Nixian Zhao, Yueling Zhao, Fengying Shi, Shiqi Yin, Dongxing Chen, Ying Yu, Cong Dong, Wenyi Mi
The paper identifies PANK1β and PANK3 as substrates of the Arg/N-degron pathway, revealing two distinct E3 ligase systems that regulate CoA biosynthesis through ubiquitin-dependent degradation.
bioRxiv · Sep 17, 2026 · PreprintMolecular Biology