Author

Cong Dong

Tianjin Medical UniversityORCID 0000-0002-2891-8759Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:protein structure prediction· 3 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Jinrong MiniD· 3 shared Aiping DongiD· 2 shared Yanjun LiiD· 2 shared Aliakbar Khalili Yazdi· 1 shared Boju Wang· 1 shared C.H. ArrowsmithiD· 1 shared Caroline Schild‐PoulteriD· 1 shared Chakrapani SubramanyamiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMolecular Biology

Jinrong MinORCID

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Author profile →

4 papers

Recent·Most cited

Parallel Arg/N-degron recognition systems regulate coenzyme A biosynthesis

Xiaolu Wang, Boju Wang, Liang Zhang, Shuxin Yan, Nixian Zhao, Yueling Zhao, Fengying Shi, Shiqi Yin, Dongxing Chen, Ying Yu, Cong Dong, Wenyi Mi

The paper identifies PANK1β and PANK3 as substrates of the Arg/N-degron pathway, revealing two distinct E3 ligase systems that regulate CoA biosynthesis through ubiquitin-dependent degradation.

bioRxiv · Sep 17, 2026 · PreprintMolecular Biology

A chemical probe to modulate human GID4 Pro/N-degron interactions

Dominic D. G. Owens, Matthew E. R. Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin P. Schwalm, Raquel A. C. Machado, Nicolas Bauer, Xu Wang, Magdalena M. Szewczyk, Cong Dong, Aiping Dong, P. Loppnau, Matthew F. Calabrese, Matthew Dowling, , C.H. Arrowsmith

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

Nature Chemical Biology · May 21, 2024Peer-reviewedMolecular Biology

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

Dong Cheng, Reiko Nakagawa, Kyohei Oyama, Yusuke Yamamoto, Weilian Zhang, Aiping Dong, Yanjun Li, Yuriko Yoshimura, Hiroyuki Kamiya, Jun‐ichi Nakayama, Jun Ueda, Jinrong Min

This study shows PHF1 and PHF19 Tudor domains preferentially bind H3tK27me3 over canonical H3K27me3, revealing structural basis for their recognition.

eLife · Sep 1, 2020Peer-reviewedMolecular Biology

Structural basis for the binding selectivity of human CDY chromodomains

Dong Cheng, Yanli Liu, Tian‐Jie Lyu, Serap Beldar, Kelsey N. Lamb, W. Tempel, Yanjun Li, Zoey Li, Lindsey Ingerman James, Qin Su, Yun Wang, Jinrong Min

This study determines the structural basis for CDY chromodomain selectivity in binding lysine-methylated ARKS motifs, revealing distinct preferences for H3K9me3 and H3K27me3.

Cell chemical biology · May 28, 2020Peer-reviewedMolecular Biology