Spinal cord extracts from sporadic ALS induce and propagate TDP-43 pathology in cerebral organoids
Yoshitaka Tamaki, Jay P. Ross, Paria Alipour, Charles-Etienne Castonguay, Boting Li, Hélène Catoire, Daniel L. Rochefort, Makoto Urushitani, Ryōsuke Takahashi, Joshua Aaron Sonnen, Stefano Stifani, Patrick A. Dion, Guy Armand Rouleau
The paper shows that spinal cord extracts from sporadic ALS patients induce and spread TDP-43 pathology in human cerebral organoids, mimicking ALS pathophysiology.
PLoS Genetics · Feb 6, 2023Peer-reviewedNeuroscience