Inferring Multi-Organ Genetic Causal Connections using Imaging and Clinical Data through Mendelian Randomization
Juan Shu, Rong Zheng, Julio A. Chirinos, Carlos Copana, Bingxuan Li, Zirui Fan, Xiaochen Yang, Yilin Yang, Xiyao Wang, Yujue Li, Bowei Xi C, Tengfei Li, Hongtu Zhu B, Bingxin Zhao
This study uses Mendelian randomization to identify genetic causal links between 58 diseases, 56 imaging traits, and multiple organs across 402 imaging traits and 372 clinical outcomes.
Nature Biomedical Engineering · Nov 19, 2025Peer-reviewedGenetic & Genomic Medicine