Bingxuan Li

DYNAMIC CONFORMATIONS IN THE ACTIVATION OF PINK1 KINASE

This study identifies conformational dynamics and dimer formation in TcPINK1, showing their role in Parkin recruitment and mitophagy.

Inferring Multi-Organ Genetic Causal Connections using Imaging and Clinical Data through Mendelian Randomization

This study uses Mendelian randomization to identify genetic causal links between 58 diseases, 56 imaging traits, and multiple organs across 402 imaging traits and 372 clinical outcomes.

PennPRS: a centralized cloud computing platform for efficient polygenic risk score training in precision medicine

PennPRS provides a cloud platform for training polygenic risk scores without individual-level data, validated with simulations and real data across 6,000 phenotypes.

Analyzing bivariate cross-trait genetic architecture in GWAS summary statistics with the BIGA cloud computing platform

The paper introduces BIGA, a cloud platform for analyzing cross-trait genetic architecture using GWAS summary statistics, enabling unified data analysis and resource sharing.

Multi-organ imaging-derived polygenic indexes for brain and body health

The paper uses genetic data to predict imaging-derived phenotypes from the UK Biobank, creating polygenic scores that identify disease risk in external cohorts.

The role of sleep in the human brain and body: insights from multi-organ imaging genetics

This study identifies genetic overlaps between sleep traits and multi-organ imaging biomarkers, showing strong genetic links between sleep and psychiatric disorders.