Author

Bradley J. Backes

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alexis N. BrumwelliD· 1 shared Dean SheppardiD· 1 shared Dustin J. MalyiD· 1 shared Feroz R. PapaiD· 1 shared Gayani Perara· 1 shared Harold A. ChapmaniD· 1 shared Maike Thamsen· 1 shared Rajarshi GhoshiD· 1 shared

Activity by Year

2019-2019 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Alexis N. BrumwellORCID

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1 paper

Recent·Most cited

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Maike Thamsen, Rajarshi Ghosh, Vincent C. Auyeung, Alexis N. Brumwell, Harold A. Chapman, Bradley J. Backes, Gayani Perara, Dustin J. Maly, Dean Sheppard, Feroz R. Papa

This study shows that inhibiting IRE1α kinase/RNase reduces lung fibrosis in mice by blocking the terminal UPR, with two compounds demonstrating efficacy in preventing and reversing fibrosis.

PLoS ONE · Jan 9, 2019Peer-reviewedMolecular Biology