Vincent C. Auyeung

This study compares molecular features of SSc-NSIP and SSc-UIP with IPF, finding shared epithelial changes and distinct fibroblast programs.

The paper identifies MMP1high basal cells derived from alveolar type II cells that contribute to microcyst formation in IPF, suggesting a therapeutic target through MMP inhibition or WNT modulation.

This study identifies senescent fibroblasts in lung cancer stroma that alter tumor metabolism and plasticity, and shows that targeting these cells with XL888 reduces tumor burden.

This study shows that aged fibroblasts activate NF-kB, leading to immune changes like exhausted T cells, autoimmunity, and cancer, increasing susceptibility to age-related diseases.

This study identifies impaired myofibroblast proliferation as a central feature of alveolar simplification in BPD using single-cell RNA sequencing and pharmacologic approaches.

This study shows that inhibiting IRE1α kinase/RNase reduces lung fibrosis in mice by blocking the terminal UPR, with two compounds demonstrating efficacy in preventing and reversing fibrosis.