Female resistance to the metabolic benefits of protein restriction is reversed by ovariectomy in mice
Bailey A. Knopf, Isaac Grunow, Brady Anderson, Tareq Rihawi, Michelle M. Sonsalla, Mariah F. Calubag, Reji Babygirija, Yang Liu, Fan Xiao, Chung‐Yang Yeh, Dudley W. Lamming
This study shows that ovariectomy in female mice enhances their metabolic response to a low protein diet, aligning it with males, while castration has little effect on males.
bioRxiv · Apr 3, 2026 · PreprintPhysiology