An Endocytic Checkpoint Controls Macrophage PD-1 Function and Immunotherapy Fate
Madhubanti Mullick, Ella McLaren, Suchismita Roy, Brandon Biagas, Mahitha Shree Anandachar, Vanessa Castillo, Samuel Williams, Celia R. Espinoza, Courtney Tindle, Gajanan Dattatray Katkar, Patricia A. Thistlethwaite, Saptarshi Sinha, Pradipta Ghosh
This paper identifies GIV as a macrophage-intrinsic factor that controls PD1 endocytosis, determining durable response versus hyperprogressive disease to PD1 blockade.
bioRxiv · Apr 17, 2026 · PreprintCancer Biology