Courtney Tindle

A stromal-state dichotomy governs recalcitrance or remission in inflammatory bowel disease

This paper identifies two stromal states in IBD that predict clinical outcomes and shows that targeting one state can reverse disease pathology.

An Endocytic Checkpoint Controls Macrophage PD-1 Function and Immunotherapy Fate

This paper identifies GIV as a macrophage-intrinsic factor that controls PD1 endocytosis, determining durable response versus hyperprogressive disease to PD1 blockade.

A NOD2-Encoded Toggle Switch Resolves the Host-Microbe Battle Over Cyclic AMP Control

This paper identifies a host-encoded toggle switch involving NOD2 and GIV that controls cAMP levels in macrophages, converting tolerant cells into microbicidal machines to restore microbial clearance and gut barrier integrity.

F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery

F.O.R.W.A.R.D is a network-based target prioritization framework that uses clinical outcomes and transcriptomic data to predict drug efficacy in IBD, achieving 100% predictive accuracy in benchmarking.

AI-guided discovery of the invariant host response to viral pandemics

The paper identifies a conserved 166-gene host immune signature across viral pandemics, with a 20-gene subset predicting disease severity and guiding therapeutic strategies.