Vanessa Castillo

Targeting catecholate siderophore systems enables precision depletion of gut enterobacteria during colitis

This study shows that targeting catecholate siderophore systems reduces AIEC colonization in colitis by immunization, preserving gut microbiome composition.

A Druggable G Protein Checkpoint in Cholesterol Efflux

The paper identifies GIV as a macrophage checkpoint suppressing reverse cholesterol transport and shows its inhibition restores cholesterol efflux, reducing plaque burden and systemic lipid overload.

An Endocytic Checkpoint Controls Macrophage PD-1 Function and Immunotherapy Fate

This paper identifies GIV as a macrophage-intrinsic factor that controls PD1 endocytosis, determining durable response versus hyperprogressive disease to PD1 blockade.

Distinct Colitis-Associated Macrophages Drive NOD2-Dependent Bacterial Sensing and Gut Homeostasis

The paper identifies niColAMs as critical for IBD recovery and shows GIV-NOD2 interaction is essential for microbial sensing and gut homeostasis.

MS/MS Mass Spectrometry Filtering Tree for Bile Acid Isomer Annotation.

This paper introduces a mass spectrometry filtering tree to distinguish bile acid isomers in LC-MS/MS data and identifies a novel deoxycholyl-2-aminophenol amidate linked to whole grain consumption.

Artificial Intelligence-rationalized balanced PPARα/γ dual agonism resets the dysregulated macrophage processes in inflammatory bowel disease

The paper uses BoNE to identify dual PPARα/γ agonism as a therapeutic strategy for IBD, validated in preclinical models and patient-derived cells.

AI-guided discovery of the invariant host response to viral pandemics

The paper identifies a conserved 166-gene host immune signature across viral pandemics, with a 20-gene subset predicting disease severity and guiding therapeutic strategies.