Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage
Cellas A. Hayes, Nyah I. Morgan, Kamryn C. Thomas, M. Jake Pushie, Akshaya Vijayasankar, Brandon G. Ashmore, Kendall Wontor, Miguel A. De Leon, Nicole M. Ashpole
This study investigates the role of IGF-1 signaling in neurons and astrocytes in ischemic stroke, finding that while both contribute to protection, neither is essential for minimizing tissue damage or behavioral outcomes.
bioRxiv · Apr 2, 2023 · PreprintNeuroscience