Author

Nicole M. Ashpole

University of MississippiORCID 0000-0002-0696-2599Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Cellas A. HayesiD· 3 shared Akshaya Vijayasankar· 2 shared Brandon G. Ashmore· 2 shared Jessica P. S. Marshall· 2 shared Daniel B. Owens· 1 shared Erik L. HodgesiD· 1 shared Julie A. Farley· 1 shared Kamryn C. Thomas· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Cellas A. HayesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage

Cellas A. Hayes, Nyah I. Morgan, Kamryn C. Thomas, M. Jake Pushie, Akshaya Vijayasankar, Brandon G. Ashmore, Kendall Wontor, Miguel A. De Leon, Nicole M. Ashpole

This study investigates the role of IGF-1 signaling in neurons and astrocytes in ischemic stroke, finding that while both contribute to protection, neither is essential for minimizing tissue damage or behavioral outcomes.

bioRxiv · Apr 2, 2023 · PreprintNeuroscience

IGF-1 Differentially Modulates Glutamate-Induced Toxicity and Stress in Cells of the Neurogliovascular Unit

Cellas A. Hayes, Brandon G. Ashmore, Akshaya Vijayasankar, Jessica P. S. Marshall, Nicole M. Ashpole

This study examines how IGF-1 signaling affects glutamate-induced toxicity and oxidative stress in neuron, astrocyte, and endothelial cells of the neuro-glio-vascular unit, showing differential responses across cell types.

Frontiers in Aging Neuroscience · Nov 23, 2021Peer-reviewedNeuroscience

Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female Mice

Cellas A. Hayes, Erik L. Hodges, Jessica P. S. Marshall, Sreemathi Logan, Julie A. Farley, Daniel B. Owens, William Edmund Sonntag, Nicole M. Ashpole

This study shows that reducing IGF-1R in adult hippocampal neurons impairs spatial learning and memory in male mice but not females, with structural changes in dendritic boutons and altered signaling pathways.

bioRxiv · Aug 8, 2021 · PreprintNeuroscience