In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity
Allon Wagner, Chao Wang, Johannes Fessler, David DeTomaso, Julián Ávila-Pacheco, James Kaminski, Sarah Zaghouani, Elena Christian, Pratiksha I. Thakore, Brandon Schellhaass, Elliot H. Akama‐Garren, Kerry A. Pierce, Vasundhara Singh, Noga Ron‐Harel, Vivian Paraskevi Douglas, , Nir Yosef
The paper introduces Compass, an algorithm that uses single-cell RNA-Seq and flux balance analysis to characterize metabolic states in Th17 cells, revealing a metabolic switch and novel anti-inflammatory regulators.
Cell · Jul 2, 2021Peer-reviewedGenomics