Subclonal IDH1/2 Mutations as a Targetable Vulnerability in Vascular Tumors
Dong-Min Yu, E L Lee, Gabriel J. Starrett, Zili Zhai, Eleanor M. Dowell, Kaitlyn Walsh, Andrew Day, Doreen N. Palsgrove, Justin Bishop, Dylan M. Marchione, Maryam Asgari, Stephen S. Chung, W.L. High, Joyce M. C. Teng, Josh Wissell, , Richard C Wang
This study identifies low-variant allele frequency IDH1/2 mutations in sporadic angiosarcoma and shows they drive tumorigenesis through non-cell-autonomous mechanisms, responding to ivosidenib treatment.
bioRxiv · May 17, 2026 · PreprintCancer Biology