Integrative Multiomics to Dissect the Lung Transcriptional Landscape of Pulmonary Arterial Hypertension
Jason S. Hong, Brenda Wong, Christopher J. Rhodes, Zeyneb Kurt, Tae-Hwi Linus Schwantes-An, Elizabeth A. Mickler, Stefan Gräf, Mélanie Eyries, Katie A. Lutz, Michael W. Pauciulo, Richard C. Trembath, David Montani, Nicholas W. Morrell, Martin R. Wilkins, William C. Nichols, , Xia Yang
The paper identifies a gene co-expression module, the pink module, associated with PAH severity, genetic risk, vascular cell types, and therapeutic targets through multiomics integration.
bioRxiv · Jan 12, 2023 · PreprintGenomics