Xia Yang

This study uses single-cell RNA sequencing to profile epicardial cell states during myocardial infarction, identifying dynamic gene programs and cell populations involved in repair and regeneration.

This study identifies magnolol and dicoumarol as natural compounds that enhance adipogenesis in multiple cell systems, offering potential for food applications and tissue engineering.

The paper quantifies gonadal and sex chromosome dosage contributions to sex differences in brain volume across multiple regions in mice, revealing their combined effects on anatomical and cellular gene expression.

The paper investigates the relative impact of gonads and sex chromosomes on sex differences in gene expression in the mouse medial septum and links these differences to sex-biased human diseases.

This study shows TMAO affects cell type-specific pathways in mouse aorta, promoting atherosclerotic plaque instability by increasing apoptosis and reducing ECM formation.

The paper identifies presynaptic and postsynaptic risk genes and key connectomes involved in pathological α-synuclein spreading using mathematical models and gene regulatory network analysis.

The paper identifies five OEC subtypes in adult rats using single-cell RNA-sequencing, revealing their hybrid glial properties and roles in neural repair.

The paper investigates the interaction between mild traumatic brain injury and genetics to identify pathway and network-level effects on learning and memory in adolescents using the ABCD cohort.

This study shows that reducing Glo1 in mice causes age- and sex-dependent metabolic issues like obesity and altered lipid metabolism without significant changes in AGEs.

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

This study shows that Δ9-THC exposure increases proliferation of naive mouse ESCs through CB1 receptor activation, with metabolic changes retained during differentiation to primordial germ cell-like cells.

This study identifies shared and distinct genetic pathways between human and mouse in coronary artery disease using multi-omics data and GWAS, showing over 75% shared pathways.

This study investigates the genetic basis of dietary iron overload and associated pathologies in mice using the Hybrid Mouse Diversity Panel, identifying genetic loci and pathways involved.

This study uses single-nucleus RNA-seq to map the adult C. elegans transcriptome and assess inter- and trans-generational effects of alcohol exposure at cell type resolution.

The paper identifies distinct subtypes of cardiac-innervating sympathetic neurons using viral tracing and single-cell RNA sequencing, revealing their unique physiological roles in stress responses.

This study identifies Prdm16 and Vcam1 as regulators of postnatal radial glia disappearance and the termination of cortical neurogenesis.

The paper identifies a gene co-expression module, the pink module, associated with PAH severity, genetic risk, vascular cell types, and therapeutic targets through multiomics integration.

This study shows T4 treatment alters cell-type specific genes, pathways, and networks in hippocampus and frontal cortex after mTBI, reversing mTBI-affected genes and pathways.

The paper identifies a Tm4sf1-marked endothelial stem/progenitor cell subpopulation in rat lungs associated with PAH and shows its relevance to human PAH through transcriptomic analysis.

SCING improves GRN inference accuracy and interpretability using gradient boosting and mutual information on scRNAseq, snRNAseq, and spatial transcriptomics data.

This study identifies oleoylethanolamide (OEA) as a key mediator by which Akkermansia muciniphila alleviates fructose-induced metabolic syndrome through gut microbiota and gut-hypothalamus axis modulation.

This study compares the effects of sex chromosome trisomies on brain anatomy in humans and mice, finding species-specific patterns and some conserved regional impacts.

This study examines sex-biased gene expression changes in mouse brain regions after adolescent THC exposure, identifying common regulatory mechanisms linked to cannabis use disorder vulnerability.

This study identifies 17 genetic risk loci for spontaneous coronary artery dissection (SCAD), including 12 new ones, and highlights genes related to artery integrity and coagulation.

CROP-Seq uses CRISPRi and scRNA-Seq to screen gene targets in adipocytes, identifying gene knock-down effects and novel regulators of adipogenesis and metabolic disease.

The paper investigates the relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in gene regulation in liver and adipose tissues using the FCG mouse model.

This study shows that early-life low-calorie sweetener consumption in rodents leads to long-term metabolic, behavioral, and neural impairments without weight gain.

The paper compares gene expression and stress responses in human and mouse astrocytes, finding conserved and divergent features that may explain differences in disease models.