The unfolded protein response of the endoplasmic reticulum protects Caenorhabditis elegans against DNA damage caused by stalled replication forks
Jiaming Xu, Brendil Sabatino, Junran Yan, Glafira Ermakova, Kelsie R. S. Doering, Stefan Taubert
This study shows that depletion of DNA primases in C. elegans activates the endoplasmic reticulum unfolded protein response (UPR-ER), which is required to alleviate replication stress.
G3 Genes Genomes Genetics · Jan 24, 2024Peer-reviewedGenetics