Using Drosophila to model a variant of unknown significance in the human cardiogenic gene Nkx2.5
TyAnna L. Lovato, Brenna Blotz, Cayleen Bileckyj, Christopher A. Johnston, Richard M. Cripps
The paper uses Drosophila to model a human Nkx2.5 variant, showing it causes DNA binding defects and reduced cofactor interaction, leading to cardiac differentiation issues.
Disease Models & Mechanisms · Sep 1, 2023Peer-reviewedDevelopmental Biology