Loss of Sox10 prevents tumor initiation and induces luminal-to-basal reprograming in a HER2+ mouse model.
Brennan Garland, Samuel Delisle, John Abou‐Hamad, Christiano de Souza, Riana Zuccarini, David P. Cook, Rebecca C. Auer, Luc A. Sabourin
This study shows that Sox10 deletion in luminal cells of HER2+ mice prevents tumor initiation and reprograms tumor cells to a basal phenotype.
bioRxiv · Aug 26, 2025 · PreprintCancer Biology