David P. Cook

The paper identifies a polarization axis in ovarian cancer cells linked to tumor architecture and survival, showing SecB cells correlate with poor prognosis and metastasis.

The paper identifies atypical B cells (ABCs) as mediators of poor response to BCG immunotherapy in high-risk NMIBC patients, linking their expansion and FCRL5 expression to early recurrence.

This study shows that postoperative stress impairs reverse cholesterol transport and accelerates atherosclerosis through inflammatory remodeling of HDL and foam cell apoptosis.

The paper identifies PI3K-gamma signaling as a key pathway in surgery-induced MDSCs that suppresses NK cells and promotes metastases, showing that targeting this pathway can reduce postoperative metastases.

This study shows that Sox10 deletion in luminal cells of HER2+ mice prevents tumor initiation and reprograms tumor cells to a basal phenotype.

This study identifies LAG3 as a marker of dysfunctional NK cells that are activated but hyporesponsive in various inflammatory conditions.

The paper identifies revSCs as regenerative cells in damaged intestinal crypts, showing TGFβ and Hippo pathways are critical for their function and intestinal regeneration.

This paper shows that LINE1 RNA is essential for maintaining hESCs by preventing the 8C state through nuclear compartmentalization and PRC2-mediated repression.

This study shows Beclin1 is required for mitosis and DNA maintenance in adult neural stem cells, leading to reduced neurogenesis.

Head-to-head on serial prostate adenocarcinoma sections: Xenium gave higher sensitivity, wider dynamic range and closer agreement with snRNA-seq; CosMx segmented cells better out of the box.

The paper uses scRNA-seq to identify disease-specific endothelial and stromal cell populations involved in arterial remodeling in PAH, highlighting TM4SF1 as a potential therapeutic target.

The paper uses single-cell RNA-Seq to study neural stem cell (NSC) defects in 3xTG-AD mice, finding reduced NSC activation and impaired neurogenesis linked to AD pathology.