Author

John Abou‐Hamad

University of OttawaORCID 0009-0004-9407-9043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

David P. CookiD· 3 shared Sarah NersesianiD· 2 shared Abrar Ul Haq KhaniD· 1 shared Anne-Marie Mes Masson· 1 shared Anne-Marie Mes-Masson· 1 shared Athena Southworth· 1 shared Ayad AliiD· 1 shared Basile Tessier Cloutier· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

David P. CookORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancer

Sarah Nersesian, John Abou‐Hamad, Emma Durocher, Gaëlle Akiki, Céline Domecq, Athena Southworth, Katrina N. Verey, Hugh H. Deng, Yudith Ramos-Valdes, Liliane Meunier, Manon de Ladurantaye, Trevor G. Shepherd, Anne-Marie Mes Masson, Anne-Marie Mes-Masson, Basile Tessier Cloutier, David P. Cook

The paper identifies a polarization axis in ovarian cancer cells linked to tumor architecture and survival, showing SecB cells correlate with poor prognosis and metastasis.

bioRxiv · Oct 22, 2026 · PreprintCancer Biology

Loss of Sox10 prevents tumor initiation and induces luminal-to-basal reprograming in a HER2+ mouse model.

Brennan Garland, Samuel Delisle, John Abou‐Hamad, Christiano de Souza, Riana Zuccarini, David P. Cook, Rebecca C. Auer, Luc A. Sabourin

This study shows that Sox10 deletion in luminal cells of HER2+ mice prevents tumor initiation and reprograms tumor cells to a basal phenotype.

bioRxiv · Aug 26, 2025 · PreprintCancer Biology

LAG3 marks activated but hyporesponsive NK cells.

Valeria Vasilyeva, Olivia Makinson, Cynthia S. Y. Chan, M. Park, Colin O’Dwyer, Ayad Ali, Abrar Ul Haq Khan, Christiano Tanese de Souza, Mohamed S. Hasim, Sara Asif, Reem Kurdieh, John Abou‐Hamad, Edward Yakubovich, Jonathan J. Hodgins, Paul Al Haddad, , Marie Marotel

This study identifies LAG3 as a marker of dysfunctional NK cells that are activated but hyporesponsive in various inflammatory conditions.

European Journal of Immunology · Jul 1, 2025Peer-reviewedImmunology