SNX13 and SNX14 interorganelle tethers suppress lysosome membrane damage and neurodegeneration
Kaitlynn Gov, Vanessa Sánchez, Emma Reynolds, Caroline Bickerton, Teresa Jimenez, Sanghee Yun, Ipsita Chakraborty, Raunaq Deo, Daniel Smith, Thomas Roulé, Blessy Paul, Sonakshi Srivastava, Amelia J. Eisch, Ophir Shalem, Xilma Rosa Ortiz-Gonzalez, , Naiara Akizu
This study identifies SNX13 and SNX14 as proteins that maintain lysosome membrane integrity and prevent neurodegeneration by supporting lipid homeostasis and repair mechanisms.
medRxiv · Oct 23, 2026 · PreprintGenetic & Genomic Medicine