Thomas Roulé

This study identifies SNX13 and SNX14 as proteins that maintain lysosome membrane integrity and prevent neurodegeneration by supporting lipid homeostasis and repair mechanisms.

GNOMES normalizes and analyzes ChIP-seq and CUT&RUN data, providing differential binding results and quality control metrics through an integrated workflow.

The paper identifies YAP1 and QSER1 as key regulators of developmental signaling pathways in the mammalian epiblast, showing their role in maintaining pluripotency and preventing excessive differentiation.

This study shows that YAP activity levels control the elongation of h3D-gastruloids by affecting the establishment of anterior and posterior domains.

The paper constructs a single-cell chromatin accessibility atlas in rice and compares it across grass species to study the evolution of cell-type-specific cis-regulatory elements.

The paper identifies YAP1 as a non-canonical effector of RA signaling essential for atrial lineage commitment in cardiac progenitor cells.

This study shows that IMPDH2 filaments protect neurons from degeneration in AMPD2 deficiency by preventing GTP deprivation.

This paper establishes a pipeline for high-quality single-cell and nuclei suspensions of gastrulating mouse embryos to enable single-cell sequencing analysis of mutant embryos.

The paper identifies CNVs in KOLF2.1J iPSCs linked to neurological disorders, showing they arose in vitro and affect gene expression in neural cells.

The paper identifies the lncRNA MARS as a regulator of epigenetic reprogramming in the Arabidopsis marneral cluster in response to ABA, modulating chromatin structure and gene expression.