Vanessa Sánchez

This study identifies SNX13 and SNX14 as proteins that maintain lysosome membrane integrity and prevent neurodegeneration by supporting lipid homeostasis and repair mechanisms.

This study shows that SNX14 deficiency causes cerebellar neurodegeneration through lipid metabolism defects and identifies a unique lipid metabolite profile linking acylcarnitine accumulation to neuronal loss.

The paper identifies enhancers for targeting specific neuronal subtypes across species and demonstrates their utility in circuit manipulation.