Blessy Paul

This study identifies SNX13 and SNX14 as proteins that maintain lysosome membrane integrity and prevent neurodegeneration by supporting lipid homeostasis and repair mechanisms.

The paper maps the human ER subdomain proteome, identifies CLMN as an ER-actin tether at focal adhesions, and shows it promotes cell migration by regulating actin dynamics and calcium signaling.

This paper shows that blocking lipid synthesis in Drosophila fat body triggers a metabolic switch to glycogen storage, mediated by SREBP and HATs, supporting development but reducing lifespan and fecundity.

This paper identifies APMAP as an ER-localized antioxidant that maintains lipid and lipoprotein homeostasis, with loss of APMAP causing ER stress, lipid droplet accumulation, and altered lipoprotein maturation across multiple organisms.