Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation
Panos Theofilas, Andrew J. Ambrose, David Butler, Chao Wang, Dulce Ovando Morales, Cathrine Petersen, Brian Chin, Teddy Tat Chi Yang, Shireen Khan, Raymond A. Ng, Rakez Kayed, Celeste M M. Karch, Bruce L. Miller, Jason E. Gestwicki, Li Gan, , Lea T. Grinberg
This study shows that caspase inhibition reduces tau cleavage and neurotoxicity in iPSC-derived neurons with the V337M MAPT mutation.
Alzheimer s & Dementia · Dec 1, 2021Peer-reviewedNeuroscience