Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's and Parkinson's disease using Polygenic Risk Scores and Mendelian Randomization
Aadrita Chatterjee, Brian D Alvarez, Rakshya U Sharma, Caroline Jonson, Heather M. Wilkins, Judy Pa, Russell Howard Swerdlow, Alison Goate, Kristine Yaffe, Shea J. Andrews
This paper uses Polygenic Risk Scores and Mendelian Randomization to evaluate the causal effect of mitochondrial DNA copy number on Alzheimer's and Parkinson's disease risk.
Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedGenetic & Genomic Medicine