Shea J. Andrews

This paper investigates sex differences in genetic liability to modifiable Alzheimer's disease risk factors using polygenic risk scores and Mendelian randomization, finding limited and inconsistent sex-specific associations.

This paper evaluates cross-ancestry polygenic risk scores (PRS) for Alzheimer's disease across multi-ethnic populations, finding improved predictive accuracy in non-European groups.

The paper examines how combined genetic, familial, and lifestyle risk factors affect plasma biomarkers in cognitively unimpaired adults, finding that higher risk burden correlates with specific biomarker changes.

This paper uses Polygenic Risk Scores and Mendelian Randomization to evaluate the causal effect of mitochondrial DNA copy number on Alzheimer's and Parkinson's disease risk.

This paper constructs a genomic-informed dementia risk score combining genetic and clinical factors and finds that most memory clinic patients have at least one high-risk indicator, with higher burden linked to increased dementia risk.

This study examines how telomere length, epigenetic age, and mitochondrial DNA abundance interact in Alzheimer's Disease, finding that their combination affects grey-matter volume.

This study performs a genome-wide association study for Long COVID, identifying a significant association with the FOXP4 locus and highlighting the role of pulmonary dysfunction and COVID-19 severity.

This study uses Mendelian randomization to examine causal relationships between sleep apnea and Alzheimer's disease, coronary artery disease, and stroke, finding significant causal effects for CAD and stroke but not AD.

The paper investigates the association between mitochondrial genome abundance and Alzheimer's disease, finding lower abundance correlates with worse neuropathology and cognitive performance.

This study updates the genetic architecture of COVID-19 by adding 11 new genome-wide significant loci through a large GWAS meta-analysis.

This study identifies genetic loci associated with SARS-CoV-2 susceptibility and disease severity using GWAS and colocalization, and links them to eQTLs in various tissues.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

The paper develops a method to impute missing mitochondrial DNA variants using a large reference alignment, improving haplogroup assignment and enabling better integration of mtDNA data from different sources.

This paper investigates the genetic link between idiopathic pulmonary fibrosis and severe COVID-19, finding a positive genetic correlation and suggesting a causal effect of most IPF risk variants on COVID-19 severity, except for the MUC5B variant which shows protective effects.

The paper introduces GWAS-VCF, a variant call format for GWAS summary statistics, showing it is faster and more robust than tabular formats for data extraction and analysis.

This study identifies 13 genome-wide significant loci associated with SARS-CoV-2 infection or severe COVID-19 through a global meta-analysis of 49,562 patients.

The paper investigates mitochondrial pathway polygenic risk scores and finds associations with increased Alzheimer's Disease risk in a cohort from the Alzheimer's Disease Neuroimaging Initiative.

This study uses Mendelian randomization to assess causal relationships between 22 risk factors and the Alzheimer's phenome, finding education, blood pressure, cholesterol, smoking, and BMI have causal effects.

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

This study uses Mendelian randomization to investigate if alcohol consumption causally affects Alzheimer's disease risk or age of onset, finding no causal link to risk but an earlier onset with consumption.

The paper investigates how mitochondrial DNA haplogroups and a polygenic risk score interact to influence dementia risk and age of onset.

This study uses Mendelian randomization to find no causal link between TNF expression, serum TNF- levels, or RA and Alzheimer’s disease risk.

This study examines the association of environmental and genetic risk scores with cognitive performance in older adults, finding the environmental risk index more strongly linked to dementia-related cognitive decline.

This study links Alzheimer's disease genetic risk loci to incident Mild Behavioral Impairment using a genetic risk score and logistic regression analysis.