A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types.
Careen Foord, Andrey D. Prjibelski, Wen Hu, Lieke Michielsen, Andrea Vandelli, Oleksandr Narykov, Brian Evans, Justine Hsu, Natan Belchikov, Julien Jarroux, Yi He, Margaret Elizabeth Ross, Iman Hajirasouliha, Gian Gaetano Tartaglia, Dmitry Korkin, , Hagen Tilgner
The paper introduces a spatial long-read sequencing method to study developmental splicing and polyadenylation changes in cortical layers and cell types, finding layer-specific and age-related regulatory patterns.
Nature Communications · Aug 29, 2025Peer-reviewedGenomics