Justine Hsu

The paper introduces a spatial long-read sequencing method to study developmental splicing and polyadenylation changes in cortical layers and cell types, finding layer-specific and age-related regulatory patterns.

The paper develops a high-resolution spatial long-read sequencing method and software to analyze isoform variability in brain cell types, revealing both region-specific and cell-type-specific patterns.

The paper predicts cell-type-specific exon inclusion in human brain cells using RBP binding sites and genomic sequence, revealing more complex splicing mechanisms in neurons than glia.

The paper introduces ScISOr-ATAC to measure splicing and chromatin accessibility in frozen brain tissues, finding convergent and divergent patterns in different cell types and conditions.

This study compares 10x Genomics 3' and 5' assays using short and long reads, finding differences in exonic/intronic capture and transcript completeness.