An essential checkpoint for TLR9 signaling is release from 1 Unc93b1 in endosomes
Olivia Majer, Brian J Woo, Bo Liu, Erik Van Dis, Gregory M Barton
The paper identifies a mechanism by which TLR9 is restricted to endosomes through its association with Unc93b1, ensuring proper signaling and preventing autoimmunity.
bioRxiv · Sep 5, 2018 · PreprintImmunology