Bo Liu

Gq-pathway activation in hippocampal CA1 astrocytes rescues ischemia-induced memory deficits and synaptic plasticity

This study shows that activating the Gq pathway in hippocampal astrocytes improves memory and synaptic plasticity after stroke in mice.

Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis

This study shows that inflammatory macrophages suppress YAP signaling in smooth muscle cells, driving their dedifferentiation in murine deep vein thrombosis.

Regenotyping structural variants through an accurate force-calling method

The paper introduces cuteSV2, a long-read-based method for accurate structural variant regenotyping, outperforming existing methods in benchmarking.

Tumorigencity decrease in Bcl-xL deficient MDCK cells ensuring the safety for influenza vaccine production

The paper knocks out Bcl-xL in MDCK cells to reduce tumorigenicity, creating a safer cell line for influenza vaccine production.

Gut Microbial Impact on Colitis and Colitis-Associated Carcinogenesis in a Primary Sclerosing Cholangitis-IBD Model

This study develops a PSC-IBD mouse model and shows that dysbiotic microbiota and bile acid metabolism drive colitis and carcinogenesis.

Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins

This study shows that myeloid-specific thrombospondin-1 deficiency increases aortic rupture risk by suppressing extracellular matrix proteins and inflammation in aneurysms.

Let-7i-5p regulates osteogenic differentiation of bone marrow mesenchymal stem cells induced by psoralen by targeting CKIP-1

This study identifies let-7i-5p as a regulator of psoralen-induced osteogenic differentiation of BMSCs by targeting CKIP-1, offering a new therapeutic target for osteoporosis.

Overcoming the pitfalls of NGS-based molecular diagnosis of Shwachman-Diamond syndrome

The paper introduces HapICE, a method to improve variant detection in SBDS using NGS, achieving higher diagnostic accuracy than conventional methods.

KIT ligand protects against both light-induced and genetic photoreceptor degeneration

The paper shows that KIT ligand protects photoreceptor cells from light-induced and genetic degeneration by activating NRF2 and Hmox1.

rMETL: sensitive and fast mobile element insertion detection with long read realignment

rMETL detects mobile element insertions using long read realignment, improving sensitivity and reducing false positives in genomic studies.

An essential checkpoint for TLR9 signaling is release from 1 Unc93b1 in endosomes

The paper identifies a mechanism by which TLR9 is restricted to endosomes through its association with Unc93b1, ensuring proper signaling and preventing autoimmunity.