Tau deletion results in sex-dependent modulation of synaptic weakening in rat hippocampus
Liam T. Ralph, Patrick Tidball, Eric W. Salter, Brian Park, Lijia Zhang, Mengdi Wei, Lauren A. Joe, Jonathan S. Thacker, Sun-Lim Choi, Ashish Kadia, Fuzi Jin, Meng Tian, Clarrisa A. Bradley, Paul E. Fraser, Zhengping Jia, , Graham L. Collingridge
This study shows that tau deletion enhances synaptic weakening in male rats but not females, revealing sex-dependent effects on synaptic function and actin dynamics.
bioRxiv · Aug 7, 2025 · PreprintNeuroscience