Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis
BreAnne MacKenzie, Poornima Mahavadi, Yago Amigo Pinho Jannini de Sá, Brecht Creyns, Ana Lúcia Coelho, Milena S. Espíndola, Clemens Ruppert, Brian Windsor, Clemens Aigner, Cory M. Hogaboam, Andreas Günther
This study evaluates the anti-fibrotic effects of LTI-03 in IPF patient-derived precision cut lung slices, showing dose-dependent reduction of fibrotic markers.
iScience · Aug 26, 2025Peer-reviewedPharmacology & Toxicology