Dendritic cell effector mechanisms and tumor immune microenvironment infiltration define TLR8 modulation and PD-1 blockade
Daniel A. Ruiz‐Torres, Jillian Frances Wise, Brian Y. Zhao, João Paulo Oliveira–Costa, Sara Cavallaro, Peter M. Sadow, Jacy Fang, Osman Yılmaz, Amar Patel, Christopher Loosbroock, Moshe Sade-Feldman, Daniel L. Faden, Shannon L. Stott
This study investigates the combination of TLR8 agonism and PD-1 blockade in HNSCC patients, finding increased innate immune activation and dendritic cell-T cell interactions.
Frontiers in Immunology · Dec 4, 2024Peer-reviewedImmunology