Daniel L. Faden

This study identifies oncRNAs as drivers of HPV-negative head and neck cancer and shows their potential for pre-diagnostic detection.

This study identifies molecular differences between HPV-associated and HPV-independent SNSCC, showing HPV drives tumorigenesis and suggesting YAP/TAZ and PI3K inhibition as therapeutic targets.

This study identifies low HLA/B2M class I expression in ACC tumors and shows it can be reversed by interferon-ψ or STING agonists, suggesting a path for immunotherapy.

This study investigates the combination of TLR8 agonism and PD-1 blockade in HNSCC patients, finding increased innate immune activation and dendritic cell-T cell interactions.

This study shows that APOBEC mutagenesis occurs in both tumor and viral genomes in HPV+ OPSCC, suggesting a direct link between viral restriction and host mutations.