Constitutively active TrkB kinase signalling reduces actin filopodia dynamics and cell migration
Rohini Gupta, Melanie Dittmeier, Gisela Wohlleben, Vera Nickl, Thorsten Bischler, Vanessa Luzak, Vanessa Wegat, Dennis Doll, Annemarie Sodmann, Elena Bady, Georg Langlhofer, Britta Wachter, Steven Havlicek, Jahnve Gupta, Evi Horn, , Robert Blum
This study shows that constitutive TrkB kinase signalling, independent of ligand, reduces actin filopodia dynamics and cell migration, and can be inhibited by Trk inhibitors.
Cancer Gene Therapy · Jul 22, 2024Peer-reviewedNeuroscience