Vanessa Luzak

The paper uses SLAM-seq and scRNA-seq to show RNA processing and stability independently influence mRNA levels in African trypanosomes.

This study shows that constitutive TrkB kinase signalling, independent of ligand, reduces actin filopodia dynamics and cell migration, and can be inhibited by Trk inhibitors.

The paper identifies a novel mechanism in trypanosomes where inter-chromosomal interactions between an antigen coding gene and an mRNA splicing locus ensure monogenic antigen expression.