Thorsten Bischler

Host response and cell fates of human U937 monocytes upon infection with vancomycin-resistant E. faecium

This study examines how vancomycin-resistant E. faecium interacts with human U937 monocytes, showing early pro-inflammatory responses and isolate-specific cell death at later stages.

Interdependent mode of RNA recognition by the interacting KH-domain proteins KhpA and KhpB

This study shows KhpA and KhpB in Campylobacter jejuni depend on each other for RNA recognition, with KhpA using a KH domain and KhpB an atypical R3H domain.

Sex differences define the molecular and cellular phenotypes of pain resolution in dorsal root ganglia

This study identifies sex-specific molecular and cellular differences in rat dorsal root ganglia during pain resolution after nerve injury.

Staphylococcus aureus triggers isolate-specific host transcriptional responses alongside TNF-R1 regulated cell death

This study shows that different S. aureus isolates trigger unique host transcriptional responses and cell death pathways, with TNF-R1 playing a key role in regulating infection outcomes in U937 cells.

Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT

The paper identifies InvS as an RNA antagonist of PinT, revealing a post-transcriptional regulatory pair in Salmonella virulence.

Resting calcium ion fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming

The paper shows that resting calcium fluxes prevent mitochondrial fragmentation and transcriptional changes in astrocytes by modulating ER stress and gene expression.

Condensation of the RNA chaperone Hfq is coupled to inhibition of carbon assimilation and contributes to the stabilisation of regulatory RNAs in nitrogen starved Escherichia coli

This study shows that Hfq condensation in E. coli during nitrogen starvation inhibits carbon assimilation and stabilizes regulatory RNAs.

A small protein essential for flagellar assembly and virulence of Campylobacter jejuni

This study identifies a small protein, PflE, essential for flagellar assembly and virulence in Campylobacter jejuni by using transposon sequencing in a humanized tissue model.

Internal in-frame translation generates Cas11b, which is important for effective interference in an archaeal CRISPR-Cas system

The paper identifies Cas11b as an internally translated protein in an archaeal CRISPR-Cas system, showing its necessity for effective interference and Cascade complex formation.

Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability

The paper identifies two conserved residues in Hfq critical for stabilizing small regulatory RNAs under nitrogen starvation.

Provirus deletion from Haloferax volcanii affects motility, stress resistance and CRISPR RNA expression

The paper deletes four proviruses in Haloferax volcanii and finds increased motility, stress resistance, and altered CRISPR RNA expression.

Human dorsal root ganglia after plexus injury: either preservation or loss of the multicellular unit

The paper examines human dorsal root ganglia (DRG) after plexus injury, finding two types of outcomes: neuronal preservation or loss, with implications for treatment strategies.

Constitutively active TrkB kinase signalling reduces actin filopodia dynamics and cell migration

This study shows that constitutive TrkB kinase signalling, independent of ligand, reduces actin filopodia dynamics and cell migration, and can be inhibited by Trk inhibitors.

Neuronal toxicity and recovery from early bortezomib-induced neuropathy: targeting the blood nerve barrier but not the dorsal root ganglion

This study investigates bortezomib-induced neuropathy in rats and patients, showing that early toxicity targets the blood nerve barrier, which can recover through upregulation of netrin-1.

Adult dorsal root ganglion glial cells exhibit neurogenic potential upon reprogramming

This study shows adult mouse DRG glial cells can dedifferentiate into neural progenitor-like cells and express neuronal and glial markers, suggesting potential for sensory circuit regeneration.

READemption 2: Multi-species RNA-Seq made easy

READemption 2.0 simplifies multi-species RNA-seq analysis by automating data processing, alignment, and differential expression analysis across multiple species.