Author

Brittany Hewitson

BC Cancer Agency

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:spatial domain detection· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Allen W. ZhangiD· 2 shared Andrew McPhersoniD· 2 shared Ciara H. O’FlanaganiD· 2 shared Daniel LaiiD· 2 shared Jamie L. Lim· 2 shared Jessica Nell McAlpineiD· 2 shared Kieran R. CampbelliD· 2 shared Matt WiensiD· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Allen W. ZhangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The variant catalogue pipeline: A workflow to generate a background variant library from Whole Genome Sequences

Solenne Correard, Mohammed OE Abdallah, Brittany Hewitson, Wyeth W. Wasserman

The paper introduces a variant catalogue pipeline to generate high-quality variant libraries from whole genome sequences, applied to 100 human genomes to improve variant cataloguing for diverse populations.

bioRxiv · Oct 3, 2022 · PreprintBioinformatics

Dissociation of solid tumour tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase associated stress responses

The CRUK IMAXT Grand Challenge Team, Ciara H. O’Flanagan, Kieran R. Campbell, Allen W. Zhang, Farhia Kabeer, Jamie L. Lim, Justina Biele, Peter D. Eirew, Daniel Lai, Andrew McPherson, Esther Kong, Cherie Bates, Kelly Borkowski, Matt Wiens, Brittany Hewitson, , Samuel A. J. R. Aparicio

This study identifies transcriptional stress responses in single-cell RNA-seq data from dissociated tumour tissues, showing that collagenase digestion induces a conserved stress response minimized by cold active protease.

Genome biology · Oct 17, 2019Peer-reviewedGenomics

Probabilistic cell type assignment of single-cell transcriptomic data reveals spatiotemporal microenvironment dynamics in human cancers

Allen W. Zhang, Ciara H. O’Flanagan, Elizabeth A. Chavez, Jamie L. Lim, Andrew McPherson, Matt Wiens, Pascale Walters, Tim Chan, Brittany Hewitson, Daniel Lai, Anja Mottok, Clémentine Sarkozy, Lauren C. Chong, Tomohiro Aoki, Xuehai Wang, , Sohrab P. Shah

CellAssign probabilistically assigns cell types to scRNA-seq data, revealing spatiotemporal dynamics in human cancers like ovarian and follicular lymphoma.

bioRxiv · Jan 16, 2019 · PreprintBioinformatics