GenomicsGenome biologyPeer-reviewed
Dissociation of solid tumour tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase associated stress responses
The CRUK IMAXT Grand Challenge Team, Ciara H. O’Flanagan, Kieran R. Campbell…·Samuel A. J. R. Aparicio
This study identifies transcriptional stress responses in single-cell RNA-seq data from dissociated tumour tissues, showing that collagenase digestion induces a conserved stress response minimized by cold active protease.